Breath biomarkers in environmental health science: exploring patterns in the human exposome.
نویسندگان
چکیده
The human genome is the counterpart to the human exposome with respect to the gene × environment interaction that describes health state and outcome. The genome has already been sequenced and is in the process of being assessed for specific functionality; to similarly decode the exposome will require the measurement and interpretation of suites of biomarker compounds in biological media such as blood, breath and urine. Of these, exhaled breath provides some important advantages for community or population-based studies in that the supply is essentially unlimited, the sampling procedures are non-invasive and can be self-administered, and there are little, if any, infectious wastes generated. The main concerns are to document a variety of compounds in breath, to assess what compounds and concentrations are considered statistically 'normal' in the healthy or unremarkably exposed population, and what graphic and mathematical approaches can be applied to assess outlier measurements as perturbations to the healthy exposome. In this paper, we explore a data set of exhaled breath measurements of exogenous exposures to jet fuel and develop summary statistics and variable clustering methods to establish between-group and intrinsic within-sample patterns that could be used to assess the status of random subjects.
منابع مشابه
O-16: Human Dietary Patterns and SemenQuality
Background: Are dietary patterns, substantiated by biomarkers, associated with semen quality? Materials and Methods: In 161 men of subfertile couples undergoing in vitro fertilization treatment in a tertiary referral clinic in Rotterdam, the Netherlands, we assessed nutrient intakes and performed principal component factor analysis to identify dietary patterns. Total homocysteine (tHcy), folate...
متن کاملThe Exposome Paradigm in Human Health: Lessons from the Emory Exposome Summer Course
The environment plays a major role in human health, yet tools to study the health impacts of complex environmental exposures are lacking. In 2005, Christopher Wild introduced the concept of the exposome, which encompasses environmental exposures and concomitant biological responses throughout the life course. Exposome-based approaches have the potential to enable novel insights into numerous re...
متن کاملCellular respiration: replicating in vivo systems biology for in vitro exploration of human exposome, microbiome, and disease pathogenesis biomarkers.
متن کامل
The Human Early-Life Exposome (HELIX): Project Rationale and Design
BACKGROUND Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure-health effect relationships. The "exposome" concept encompasses the totality of exposures from conception onward, complementing the genome. OBJECTIVES The Human Early-Life Exposome (HELIX) project is a new co...
متن کاملSequencing the exposome: A call to action☆
The exposome is a complement to the genome that includes non-genetic causes of disease. Multiple definitions are available, with salient points being global inclusion of exposures and behaviors, and cumulative integration of associated biologic responses. As such, the concept is both refreshingly simple and dauntingly complex. This article reviews high-resolution metabolomics (HRM) as an afford...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of breath research
دوره 5 4 شماره
صفحات -
تاریخ انتشار 2011